Implication of gelatinases in retinoblastoma development.

نویسندگان

  • Adina Zamfir-Chiru-Anton
  • Cristian Gheorghe Dan
چکیده

The aim of this paper was to reveal the latest clinical and research findings regarding the implications of MMP2 and MMP9 matrix metalloproteinases in retinoblastoma development. The targets were finding better options for the therapeutic approach, considering the etiopathogeny and biology of this tumor.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

مروری بر رتینوبلاستوما و گزارش سه مورد رتینوبلاستوم دوطرفه

Retinoblastoma is a retinal malignant tumor that occurs in early childhood. The annual incidence of retinoblastoma is approximately one per 14 000 live births. 250 to 300 new cases are reported in the United States each year. It develops due to inactivation of both alleles of the retinoblastoma susceptibility (RB1) gene. All hereditary cases (55%) are with bilateral and multifocal lesions, but ...

متن کامل

Molecular Investigation of the Human Adenovirus in Retinoblastoma Patients

Background and Aims: Retinoblastoma tumors are the most common intraocular malignancy in childhood, leading to death after two years. The Human Adenovirus (HAdV) infection could be critical in the retinoblastoma pathogenesis due to the virus and retinoblastoma 1 interactions. The objective of the current study was to investigate the possible presence of the HAdV genome in the retinoblastoma pat...

متن کامل

Cytotoxicity effect of gold nanoparticles against a rabbit model of retinoblastoma

Introduction: Retinoblastoma is a malignant tumor in children. The goal of retinoblastoma treatment is to maintain vision and minimize side effects. In this study, the toxicity of the gold nanoparticle safety in vitro was investigated on an eye tumor of retinoblastoma under in vivo conditions. Materials and Methods: For the evaluation of the toxicity of gold nanoparticles using MTT test after 4...

متن کامل

Quantification of Mean Vessel Density in Retinoblastoma and Its Correlation with Local Tumor Invasion and Patients Survival

  Background and Objectives: Retinoblastoma is the most common intraocular pediatric malignancy. Angiogenic factor expression such as VEGF (vascular endothelial growth factor) in retinoblastoma can be confirmatory angiogenic potential of this tumor. This study was performed to determine the role of angiogenesis in local invasion of retinoblastoma and its correlation with patients’ sur...

متن کامل

A Review of Outstanding Retinoblastoma Researches on RB1 Genes: Focus on Treatment by Non-ionizing and Ionizing Radiation

Introduction: Retinoblastoma (RB) is a malignant retinal tumor, which affects infants and children. This cancer happens through a mutation in the retinoblastoma tumor suppressor genes (RB1). Inactivation of RB1 has been observed in more than 97% of all retinoblastoma patients with mutations. In recent years, RB treatment has developed significantly. RBchr('39')s treatment methods can be one or ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Romanian journal of ophthalmology

دوره 60 2  شماره 

صفحات  -

تاریخ انتشار 2016